The effects of dopaminergic medication on dynamic decision making in Parkinson's disease.
Identifieur interne : 000904 ( Main/Exploration ); précédent : 000903; suivant : 000905The effects of dopaminergic medication on dynamic decision making in Parkinson's disease.
Auteurs : Magda Osman [Royaume-Uni] ; Agata Ryterska [Royaume-Uni] ; Kash Karimi [Royaume-Uni] ; Lingling Tu [République populaire de Chine] ; Ignacio Obeso [Canada] ; Maarten Speekenbrink [Royaume-Uni] ; Marjan Jahanshahi [Royaume-Uni]Source :
- Neuropsychologia [ 1873-3514 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Cues, Decision Making (drug effects), Dopamine Agents (pharmacology), Dopamine Agents (therapeutic use), Female, Goals, Humans, Learning (drug effects), Levodopa (pharmacology), Levodopa (therapeutic use), Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (drug therapy), Task Performance and Analysis.
- MESH :
- chemical , pharmacology : Dopamine Agents, Levodopa.
- drug effects : Decision Making, Learning.
- drug therapy : Parkinson Disease.
- chemical , therapeutic use : Dopamine Agents, Levodopa.
- Aged, Cues, Female, Goals, Humans, Male, Middle Aged, Neuropsychological Tests, Task Performance and Analysis.
Abstract
In the present study we address the following questions: (1) How is performance affected when patients with Parkinson's Disease (PD) perform a dynamic decision making task? (2) Does dopaminergic medication differentially affect dynamic decision making? To address these questions participants were trained with different goals during learning: either they made intervention-based decisions or prediction-based decisions during learning. The findings show that overall there is an advantage for those trained to intervene over those trained to predict. In addition, the results are the first demonstration that PD patients 'ON' (N=20) compared to 'OFF' L-Dopa (N=15) medication and also relative to healthy age matched controls (N=16) showed lower levels of relative improvement in the accuracy of their decisions in a dynamic decision making task, and tended to use sub-optimal strategies. These findings provide support for the 'Dopamine Overdose' hypothesis using a novel decision making task, and suggest that executive functions such as decision making can be adversely affected by dopaminergic medication in PD.
DOI: 10.1016/j.neuropsychologia.2013.10.024
PubMed: 24269857
Affiliations:
- Canada, Royaume-Uni, République populaire de Chine
- Angleterre, Grand Londres, Ontario
- Londres, Toronto
- University College de Londres, Université de Londres, Université de Toronto
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Le document en format XML
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Electronic address: M.Osman@qmul.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Biological and Experimental Psychology, School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom; Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, 33 Queen Square, London WC1N 3 BG, United Kingdom; Cognitive, Perceptual and Brain Sciences, University College London, 26 Bedford Way, London WC1H 0AP</wicri:regionArea><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ryterska, Agata" sort="Ryterska, Agata" uniqKey="Ryterska A" first="Agata" last="Ryterska">Agata Ryterska</name><affiliation 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type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Karimi, Kash" sort="Karimi, Kash" uniqKey="Karimi K" first="Kash" last="Karimi">Kash Karimi</name><affiliation wicri:level="1"><nlm:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, 33 Queen Square, London WC1N 3 BG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, 33 Queen Square, London WC1N 3 BG</wicri:regionArea><wicri:noRegion>London WC1N 3 BG</wicri:noRegion></affiliation></author><author><name sortKey="Tu, Lingling" sort="Tu, Lingling" uniqKey="Tu L" first="Lingling" last="Tu">Lingling Tu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Sir Run Run Shaw Hospital, 3 East Qingchun Road, 310016 Hangzhou, Zhejiang, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Psychiatry, Sir Run Run Shaw Hospital, 3 East Qingchun Road, 310016 Hangzhou, Zhejiang</wicri:regionArea><wicri:noRegion>Zhejiang</wicri:noRegion></affiliation></author><author><name sortKey="Obeso, Ignacio" sort="Obeso, Ignacio" uniqKey="Obeso I" first="Ignacio" last="Obeso">Ignacio Obeso</name><affiliation wicri:level="4"><nlm:affiliation>Psychology Department at the St. George Campus, University of Toronto, 100 St. George Street, 4th Floor, Sidney Smith Hall, Toronto, Ontario, Canada M5S 3G3.</nlm:affiliation><country>Canada</country><wicri:regionArea>Psychology Department at the St. George Campus, University of Toronto, 100 St. George Street, 4th Floor, Sidney Smith Hall, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Speekenbrink, Maarten" sort="Speekenbrink, Maarten" uniqKey="Speekenbrink M" first="Maarten" last="Speekenbrink">Maarten Speekenbrink</name><affiliation wicri:level="4"><nlm:affiliation>Cognitive, Perceptual and Brain Sciences, University College London, 26 Bedford Way, London WC1H 0AP, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cognitive, Perceptual and Brain Sciences, University College London, 26 Bedford Way, London WC1H 0AP</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name><affiliation wicri:level="1"><nlm:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, 33 Queen Square, London WC1N 3 BG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, 33 Queen Square, London WC1N 3 BG</wicri:regionArea><wicri:noRegion>London WC1N 3 BG</wicri:noRegion></affiliation></author></analytic><series><title level="j">Neuropsychologia</title><idno type="eISSN">1873-3514</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cues</term><term>Decision Making (drug effects)</term><term>Dopamine Agents (pharmacology)</term><term>Dopamine Agents (therapeutic use)</term><term>Female</term><term>Goals</term><term>Humans</term><term>Learning (drug effects)</term><term>Levodopa (pharmacology)</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (drug therapy)</term><term>Task Performance and Analysis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dopamine Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Decision Making</term><term>Learning</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cues</term><term>Female</term><term>Goals</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Task Performance and Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the present study we address the following questions: (1) How is performance affected when patients with Parkinson's Disease (PD) perform a dynamic decision making task? (2) Does dopaminergic medication differentially affect dynamic decision making? To address these questions participants were trained with different goals during learning: either they made intervention-based decisions or prediction-based decisions during learning. The findings show that overall there is an advantage for those trained to intervene over those trained to predict. In addition, the results are the first demonstration that PD patients 'ON' (N=20) compared to 'OFF' L-Dopa (N=15) medication and also relative to healthy age matched controls (N=16) showed lower levels of relative improvement in the accuracy of their decisions in a dynamic decision making task, and tended to use sub-optimal strategies. These findings provide support for the 'Dopamine Overdose' hypothesis using a novel decision making task, and suggest that executive functions such as decision making can be adversely affected by dopaminergic medication in PD.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Royaume-Uni</li><li>République populaire de Chine</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Ontario</li></region><settlement><li>Londres</li><li>Toronto</li></settlement><orgName><li>University College de Londres</li><li>Université de Londres</li><li>Université de Toronto</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Osman, Magda" sort="Osman, Magda" uniqKey="Osman M" first="Magda" last="Osman">Magda Osman</name></region><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name><name sortKey="Karimi, Kash" sort="Karimi, Kash" uniqKey="Karimi K" first="Kash" last="Karimi">Kash Karimi</name><name sortKey="Ryterska, Agata" sort="Ryterska, Agata" uniqKey="Ryterska A" first="Agata" last="Ryterska">Agata Ryterska</name><name sortKey="Speekenbrink, Maarten" sort="Speekenbrink, Maarten" uniqKey="Speekenbrink M" first="Maarten" last="Speekenbrink">Maarten Speekenbrink</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Tu, Lingling" sort="Tu, Lingling" uniqKey="Tu L" first="Lingling" last="Tu">Lingling Tu</name></noRegion></country><country name="Canada"><region name="Ontario"><name sortKey="Obeso, Ignacio" sort="Obeso, Ignacio" uniqKey="Obeso I" first="Ignacio" last="Obeso">Ignacio Obeso</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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